On the origin of the human influenza virus subtypes H2N2 and H3N2
Identifieur interne : 002987 ( Main/Exploration ); précédent : 002986; suivant : 002988On the origin of the human influenza virus subtypes H2N2 and H3N2
Auteurs : C. Scholtissek [Allemagne] ; W. Rohde [Allemagne] ; V. Von Hoyningen [Allemagne] ; R. Rott [Allemagne]Source :
- Virology [ 0042-6822 ] ; 1978.
Descripteurs français
- KwdFr :
- ARN viral (analyse), ARN viral (génétique), Gènes viraux, Hémagglutinines virales, Protéines virales (biosynthèse), Recombinaison génétique, Sialidase (biosynthèse), Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Séquence nucléotidique, Virus de la grippe A (génétique).
- MESH :
- analyse : ARN viral.
- biosynthèse : Protéines virales, Sialidase.
- génétique : ARN viral, Virus de la grippe A.
- Gènes viraux, Hémagglutinines virales, Recombinaison génétique, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Séquence nucléotidique.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , biosynthesis : Neuraminidase, Viral Proteins.
- chemical , genetics : RNA, Viral.
- genetics : Influenza A virus.
- Teeft :
- Animal origin, Base Sequence, Base sequence homology, Crna, Double infection, Duck ukraine, Duck ukraine strain, Equine, Fowl, Fowl plague virus, Gene, Gene coding, Gene functions, Genes, Viral, Genome, Hemagglutinin, Hemagglutinin gene, Hemagglutinins, Viral, Hlnl, Hlnl subtype, Homology, Hong kong, Hong kong strain, Hybridization, Influenza, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza virus genome, Influenza viruses, Neuraminidase, Neuraminidase gene, Other influenza, Other segments, Palese, Polyacrylamide, Polymerase, Prototype strains, Recombinant, Recombination, Genetic, Rohde, Scholtissek, Segment, Singapore, Singapore strain, Ukraine, Viral, Virology.
Abstract
Abstract: The RNA of the human influenza virus Singapore (H2N2) strain has been labeled in vivo by phosphorus-32 and separated by polyacrylamide gel electrophoresis into eight segments, which were correlated to the corresponding gene functions and/or proteins. The base sequence homology between the individual genes (segments) of the H2N2 virus and those of different influenza A strains has been determined by molecular hybridization. Segments 1, 5, 7, and 8 of the Singapore strain exhibit a base sequence homology of almost 100% as compared to the FM1 strain (HlNl), while the homology between the other segments is significantly lower (24–76%). For the Singapore and Hong Kong (H3N2) strains all segments except that coding for the hemagglutinin (HA, 24%) exhibit a homology close to 100%. The 32P-labeled segment 4 (HA-gene) of the avian influenza A strain duck Ukraine (Hav7Neg2) shows a homology of 92% to Hong Kong, while the homology of at least two other segments is significantly lower. These results are taken as an indication that the H2N2 subtype is derived from the HlN1 subtype by a recombination event retaining four H1N1 segments, while the other four segments are gained from another yet unknown strain. The H3N2 subtype is presumably derived from a H2N2 subtype, retaining seven segments of the H2N2 subtype, while the gene coding for the HA is obtained from the duck Ukraine or another highly related strain.
Url:
DOI: 10.1016/0042-6822(78)90153-8
Affiliations:
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Von Hoyningen</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Justus-Liebig-Universität Giessen, D-6300 Giessen</wicri:regionArea><wicri:noRegion>D-6300 Giessen</wicri:noRegion><wicri:noRegion>D-6300 Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Rott, R" sort="Rott, R" uniqKey="Rott R" first="R." last="Rott">R. Rott</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Justus-Liebig-Universität Giessen, D-6300 Giessen</wicri:regionArea><wicri:noRegion>D-6300 Giessen</wicri:noRegion><wicri:noRegion>D-6300 Giessen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1978">1978</date><biblScope unit="volume">87</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="13">13</biblScope><biblScope unit="page" to="20">20</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term><term>Genes, Viral</term><term>Hemagglutinins, Viral</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Neuraminidase (biosynthesis)</term><term>RNA, Viral (analysis)</term><term>RNA, Viral (genetics)</term><term>Recombination, Genetic</term><term>Viral Proteins (biosynthesis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>ARN viral (génétique)</term><term>Gènes viraux</term><term>Hémagglutinines virales</term><term>Protéines virales (biosynthèse)</term><term>Recombinaison génétique</term><term>Sialidase (biosynthèse)</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Séquence nucléotidique</term><term>Virus de la grippe A (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Neuraminidase</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Protéines virales</term><term>Sialidase</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Virus de la grippe A</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Animal origin</term><term>Base Sequence</term><term>Base sequence homology</term><term>Crna</term><term>Double infection</term><term>Duck ukraine</term><term>Duck ukraine strain</term><term>Equine</term><term>Fowl</term><term>Fowl plague virus</term><term>Gene</term><term>Gene coding</term><term>Gene functions</term><term>Genes, Viral</term><term>Genome</term><term>Hemagglutinin</term><term>Hemagglutinin gene</term><term>Hemagglutinins, Viral</term><term>Hlnl</term><term>Hlnl subtype</term><term>Homology</term><term>Hong kong</term><term>Hong kong strain</term><term>Hybridization</term><term>Influenza</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza virus genome</term><term>Influenza viruses</term><term>Neuraminidase</term><term>Neuraminidase gene</term><term>Other influenza</term><term>Other segments</term><term>Palese</term><term>Polyacrylamide</term><term>Polymerase</term><term>Prototype strains</term><term>Recombinant</term><term>Recombination, Genetic</term><term>Rohde</term><term>Scholtissek</term><term>Segment</term><term>Singapore</term><term>Singapore strain</term><term>Ukraine</term><term>Viral</term><term>Virology</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Gènes viraux</term><term>Hémagglutinines virales</term><term>Recombinaison génétique</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Séquence nucléotidique</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The RNA of the human influenza virus Singapore (H2N2) strain has been labeled in vivo by phosphorus-32 and separated by polyacrylamide gel electrophoresis into eight segments, which were correlated to the corresponding gene functions and/or proteins. The base sequence homology between the individual genes (segments) of the H2N2 virus and those of different influenza A strains has been determined by molecular hybridization. Segments 1, 5, 7, and 8 of the Singapore strain exhibit a base sequence homology of almost 100% as compared to the FM1 strain (HlNl), while the homology between the other segments is significantly lower (24–76%). For the Singapore and Hong Kong (H3N2) strains all segments except that coding for the hemagglutinin (HA, 24%) exhibit a homology close to 100%. The 32P-labeled segment 4 (HA-gene) of the avian influenza A strain duck Ukraine (Hav7Neg2) shows a homology of 92% to Hong Kong, while the homology of at least two other segments is significantly lower. These results are taken as an indication that the H2N2 subtype is derived from the HlN1 subtype by a recombination event retaining four H1N1 segments, while the other four segments are gained from another yet unknown strain. The H3N2 subtype is presumably derived from a H2N2 subtype, retaining seven segments of the H2N2 subtype, while the gene coding for the HA is obtained from the duck Ukraine or another highly related strain.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Scholtissek, C" sort="Scholtissek, C" uniqKey="Scholtissek C" first="C." last="Scholtissek">C. Scholtissek</name></noRegion><name sortKey="Rohde, W" sort="Rohde, W" uniqKey="Rohde W" first="W." last="Rohde">W. Rohde</name><name sortKey="Rott, R" sort="Rott, R" uniqKey="Rott R" first="R." last="Rott">R. Rott</name><name sortKey="Von Hoyningen, V" sort="Von Hoyningen, V" uniqKey="Von Hoyningen V" first="V." last="Von Hoyningen">V. Von Hoyningen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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